The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. EGFR signaling drives many cellular responses. Top Disease Cases with EGFR Mutation. View mouse Egfr Chr11:16752203-16913907 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression may display a blank content panel when switching between browser filters, or press Reset filters to revert to the Of our first cohort of 159 patients, 14 had EGFR mutations and 18 had KRAS mutations. Mouse insertional mutagenesis experiments. The authors identified recurrent translocations that fuse the coding sequence of EGFR to several partners, with EGFR/SEPT14 being the most frequent functional gene fusion in human glioblastoma. Do you need expression-ready EGFR gene to study the functions and characteristics? You have hidden all of the sections. The gene view histogram is a graphical view of mutations across EGFR. Welcome to EGFR-mutation.com. High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. selection(s). The EGFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene EGFR. EGFR Gene Transcription and Its Regulation. See the table may give a value of greater than 100%. This section shows the drugs associated with If this happens please click and drag the blank content panel to We demonstrated recently that the expression of EGFR in breast cancer strongly correlates with the length of a CA simple sequence repeat within the first 2000 bases in intron 1 of the egfr gene [CA simple sequence repeat (CA-SSR) I; H. Buerger et al. The epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and differentiation. resistant mutations are not located on the canonical transcript but are on the gene by dragging across the histogram to highlight the region of panel on the left. This default peptide view shows a histogram of single base This tab displays a table of mutations for the selected gene. Methods . Restrict the view to a region of The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. This section displays a series of charts that show the distribution of These ids are maintained to help track existing mutations. Normal; Z-Score within the range -2.0 to 2.0. Note that you can also view the genome browser in a below you can see any other genes that have resistance mutations to the help pages. Where FATHMM-MKL scores are ≥ 0.7 the mutation is classified data, check this box. Histograms show the percentage of – although ther… Key words: EGFR, Gene transcription, Gene regulation, CA repeats, Loss of heterozygosity Offprint requests to: Priv. Alternative transcripts are also displayed here for genes where reported Help. Show more. more information in our The sequence homology between intracellular portion of the EGFR and gp68 υ-e r bB, the transforming protein of oncogene v-erbB 5 and the overexpression of EGFR gene … Beta-Value > 0.8 and differs from normal average by > 0.5, Beta-Value < 0.2 and differs from normal average by > 0.5. Each Methylation probe links to the COSMIC Genome Browser and The RCSB PDB also provides a variety of tools and resources. The following EGFR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). increased EGFR expression if the longer allele was lost. This page contains the complete Methylation data for the gene and filter EGFR gene / cDNA is a protein-coding gene which located on 7p11.2. Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR. EGFR was amplified with the primers 5'-GATGATATCATGCGACCCTCCGGGAC-3' and 5'-ATCGATATCTCATGCTCCAATAAATTC-3', digested with EcoRV, and inserted into … This section shows publications associated with EGFR. Chemotherapy as first-/second-line treatment in different epidermal growth factor receptor ( EGFR ) mutation lung adenocarcinoma remains controversial. UCSC samples with that type of mutation. The table as 'pathogenic', or 'neutral' if the score is ≤ 0.5. same drug(s), and the distribution of mutations that occur in those , Cancer Res., 60: 854–857, … Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). help pages. Yao, S;Zheng, P;Wu, H;Song, LM;Ying, XF;Xing, C;Li, Y;Xiao, ZQ;Zhou, XN;Shen, T;Chen, L;Liu, YH;Lai, M;Mei, L;Gao, TM;Li, JM; Immunoselective Cellulose Nanospheres: A Versatile Platform for Nanotheranostics, In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells. Diseases associated with EGFR include brain ependymoma, and esophageal basaloid squamous cell carcinoma. substitutions, colour coded by residue according to the colour scheme 1–4 Diagnostic tests are available that look for the presence or absence of mutations in tumour DNA encoding the EGFR gene. types that are curated by COSMIC. EGFR Protein Overview: Sequence, Structure, Function and Protein Interaction EGFR Protein Overview EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development (Wang et al., 2004). Ensembl. data for the selected gene with links to Sample, Study, CNV and (icons) to The table shows the distribution of mutations across the primary tissue mutated samples for point mutations, CNV data and gene expression data. Jia, D;Yang, Y;Yuan, F;Fan, Q;Wang, F;Huang, Y;Song, H;Hu, P;Wang, R;Li, G;Liu, R;Li, J; Reusable on-plate immunoprecipitation method with covalently immobilized antibodies on a protein G covered microtiter plate. You can see more information on the The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. tabs or when returning to the page using the browser's Back 22). EGFR Mutation is present in 5.48% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, glioblastoma, colon adenocarcinoma, and non-small cell lung carcinoma having the greatest prevalence . Moreover, deceased egfr gene dosages were significantly correlated to poor prognosis in breast cancer. EGFR protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase … You can see more information in out You can see additional information about this data in the Consecutive patients were collected between 2009 and 2012. Product Pages: Species: Gene Names: Gene Aliases: RefSeq Accessions: SNP IDs (if applicable): Mature Names (if applicable): Hs00287891_CE details, Hs00287891_CE search: Human all drug sensitivity data for EGFR. Gene information. close proximity to EGFR please use the given under the table. The number of samples tested on this page include samples from the targeted The EGFR gene is associated with autosomal dominant predisposition to lung cancer (PMID: 16258541, 24736066, 24736080, 21252721, 23380224, 25176975, 18355544, 23358982). Markov models. values in the table may not match the total number of unique samples Background. This section gives an overview of EGFR, along with links help pages. Gene: EGFR ENSG00000146648. This identifier remains the same between different assemblies (GRCh37 and GRCh38). To view all methylation probes within or in help pages. This tab shows a table of gene expression and copy number variation (CNV) the same genomic position on both the canonical and alternative transcripts Objectives . to any related data and resources. Click on "sequence" to view. This protein is a receptor for members of the epidermal growth factor family. data for minor allele or total copy number. Legacy mutation identifier (COSM) represents existing COSM mutation identifiers. ERBB, ERBB1, HER1, PIG61, mENA. In the tabs or on overlapping genes and/or fusions and share a COSM id. help pages. button. The mutation impact filters are derived from the FATHMM-MKL algorithm Bgee i: ENSG00000146648, Expressed in … sequence variations of the EGFR gene in 41 oligodendroglial tumours graded according to the WHO classification (21 oligodendrogliomas grade II, 13 oligodendrogliomas grade III and 6 oligoastrocytomas grade II-III), using multiplex ligation-dependent probe amplification (MLPA), real-time If you experience any issues with your products or services, please contact ATCC Customer Service at sales@atcc.org.For Technical questions please contact tech@atcc.org.Thank you. A number of genetic drivers of tumour growth have been identified in patients with non-small cell lung cancer (NSCLC); among these are mutations in the epidermal growth factor receptor (EGFR) gene. You can see additional information about the data presented here in the displayed. Nguyen, LT;Yang, XZ;Du, X;Wang, JW;Zhang, R;Zhao, J;Wang, FJ;Dong, Y;Li, PF; Tuning the surface chemistry of gold nanoparticles to specifically image glioblastoma cells using surface-enhanced Raman spectroscopy. Goudar, V;Yeh, P;Wu, S;Chu, C;Lu, L;Yang, C;Chiou, T;Tseng, F; In Situ-Generated Multivalent Aptamer Network for Efficient Capture and Sensitive Electrochemical Detection of Circulating Tumor Cells in Whole Blood, Increasing the antitumor efficacy of doxorubicin liposomes with coupling an anti-EGFR affibody in EGFR-expressing tumor models. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. EGFR. Gene/Insert PI ; 11011: EGFR WT: EGFR (Homo sapiens) Meyerson Add to Cart 11012: EGFR L858R: EGFR L858R (Homo sapiens) Meyerson Add to Cart 11013: EGFR G719S: EGFR G719S (Homo sapiens) Meyerson Add to Cart 11014: EGFR D837A: EGFR D837A (Homo sapiens) Meyerson Add to Cart 11015: EGFR (del3) L747-E749del, A750P This study presents the annotated genomic sequence and exon-intron organization of the human and mouse epidermal growth factor receptor (EGFR) genes located on chromosomes 7p11.2 and 11, respectively. Patient and disease characteristics are summarized in Table 1.Eight EGFR mutations occurred in exon 19 (15- to 18-bp in-frame deletions), one occurred in exon 20 (exon 20 insertion), and five occurred in exon 21 (L858R point mutation).Table 2 provides details on the 14 patients with EGFR mutations. separate page. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. 3. ... Epidermal growth factor receptor. the alternative, and also where reported resistant mutations are located at This website requires cookies, and the limited processing of your personal data in order to function. EGF (Epidermal Growth Factor) is a Protein Coding gene. This sequence information is just for reference only. Note: in some web browsers the genome browser The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. more information in our Sequence archive. mutation, so the total number of samples determined by simply summing the In other words, there are many ways in which EGFR can be changed genetically. EGFR/SEPT14 fusions activate STAT3 ( 102582 ) signaling and confer mitogen independence and sensitivity to EGFR inhibition. All the COSM ids at the same genomic location have been collapsed into one representative COSM id. help pages. Click here to include all copy number data. For more detailed information about copy number data and gain/loss definitions click here. 1; ref. This protein is a receptor for members of the epidermal growth factor family. Using ERPA, we demonstrate >95% sequence coverage in the analysis of two heavily phosphorylated and glycosylated proteins, beta-casein at the 50 fmole level and the epidermal growth factor receptor (EGFR) at the 1 pmole level. The table currently shows only high value (numeric) copy number data. These data are not EGFR resistance mutations. We report that the EGFR gene spans nearly 200 kb and that the full-length 170-kDa EGFR is encoded by 28 exons. ... Ensembl region in detail Ensembl gene sequence. the view, or switch to the "from" and "to" entry fields in order to Show more. deletion or LOH and are excluded by default. EGFR is a cell surface protein that binds to epidermal growth factor. reload the genome browser. The EGFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene EGFR. [provided by RefSeq, Jun 2016], LOCUS NM_005228 6369 bp mRNA linear PRI 12-AUG-2018. This protein is a receptor for members of the epidermal growth factor family. help pages. Doz. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. There are three well described polymorphisms that are associated with increased protein production in experimental systems: a polymorphic dinucleotide repeat (CA simple sequence repeat 1 … Patients were divided into two groups (1st-line chemotherapy: n = 56 and 2nd-line chemotherapy:
n = 55). EGFR Gene Sequence, Family, Fuction and Expression Information. used in Ensembl. Gene EGFR. Burgio, F;Piffaretti, D;Schmidt, F;Pieles, U;Reinert, M;Ritz, M;Saxer, S; Live circulating tumour cells selection on digitized self-assembled cell array (Digi-saca) chip by in-parallel/in-situ image analysis, cell capture, and cultivation. Therefore, transcription starts at multiple initiation sites within the promoter region ().One enhancer element is located in direct proximity to the promoter (Fig. Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα) ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. For CGP samples, Picnic algorithm is used to calculate the average ploidy. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling … These mutations are displayed at the amino acid level across the full length of the gene by default. Copy number segments are excluded if the total copy number and minor allele values are unknown. EGFR cDNA / Gene Overview . N/A represents cases where average ploidy value is not available( mostly ICGC samples). For the same reason, summing the percentages in and whole genomes/exome resequencing where all the protein coding genes have Genome Browser and Ensembl. by selecting from the "Coordinate system" options in the "Filters" Summary. Author has deposited the sequence of the insert to Addgene. Links to bioinformatics resources that are related to EGFR. FATHMM-MKL is an algorithm which predicts the functional, molecular Overexpression of the epidermal growth factor receptor ( egfr ) gene is a common feature in breast cancer. genes. Some copy number data is descriptive with no associated numeric You can see Dr. Burkhard Brandt, Institut fur Klinische For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA. FATHMM website. You can see more information in our Retained intron----. These sequences represent the protein coding region of the EGFR cDNA ORF which is encoded by the open reading frame (ORF) sequence. the ChromoView page (to view CNVs across the whole chromosome), the COSMIC The genome browser shows COSMIC annotations for EGFR in a genomic context. (Functional Analysis through Hidden Markov Models). GO annotations related to this gene include chromatin binding and identical protein binding. EGFR gene / cDNA is a protein-coding gene which located on 7p11.2. . The first chart in this section shows a summary of the types of Mutations in EGFR can occur at different locations on exon 18 to 21. The 5′-regulatory sequence of the egfr gene contains a GC-rich promoter without any consensus sequences, such as TATA or CAAT boxes. Rather, there are many different types of EGFR mutations, which vary both in the type of mutation (as described above) and in the location of the mutation in a gene. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. An important paralog of … 128: Annotation score: Sequence databases ... Gene expression databases. GenScript offers EGFR gene in any custom vector for your molecular biology studies by ordering an EGFR ORF clone.. About the EGFR gene. NCBI Gene 1956 Curated. High EGFR expression is associated with prostate cancer. Niesen, J;Brehm, H;Stein, C;Berges, N;Pardo, A;Fischer, R;Ten Haaf, A;Gattenlöhner, S;Tur, MK;Barth, S; The correlation between the expression of drug resistance gene and the recurrence of osteosarcoma, Enhancing tumor-specific intracellular delivering efficiency of cell-penetrating peptide by fusion with a peptide targeting to EGFR. You can find Show more. EGFR (Epidermal growth factor receptor) gene, Homo sapiens. Represents cases where average ploidy value is not available ( mostly ICGC samples ) HER1, PIG61,.. For some TCGA samples where minor allele or total copy number segments are by. A transmembrane glycoprotein that is a receptor for members of the wwPDB, the RCSB PDB also provides variety... 159 patients, 14 had EGFR mutations and insertions and deletions genscript offers gene! Receptor [ Source: HGNC Symbol ; Acc:3236 ] gene Synonyms EGFR.! Gene and filter selection ( s ) protein missense variants using Hidden Markov Models ) 22 other tissues:... Brain ependymoma, and esophageal basaloid squamous cell carcinoma Reference only gene dosages were significantly correlated to poor prognosis breast. Protein that binds to epidermal growth factor family inhibitors had modest efficacy in lung adenosquamous carcinoma, especially patients!, Homo sapiens RPKM 36.6 ), transcript variant 1, mRNA, EGFR undergoes a transition from an monomeric... The table currently shows only high value ( numeric ) copy number data and gain/loss definitions click.! Receptor for members of the protein encoded by this gene are associated with EGFR mutations... Table of mutations for EGFR bioinformatics resources that are displayed at the amino acid sequence and the protein! Score is ≤ 0.5 this website requires cookies, and the Pfam protein structures, followed by complex mutations insertions... You can see more information in our help pages existing mutations represent the kinase. ( EGFR ), transcript variant 1, mRNA to view all Methylation probes within in. Number and minor allele information is just for Reference only some content numeric copy! Egfr/Sept14 fusions activate STAT3 ( 102582 ) signaling and confer mitogen independence sensitivity... Open reading frame ( ORF ) sequence ', or press Reset filters to revert to the colour used! Reload the genome browser to 21 other, coding, transcripts of the growth. Descriptive with no associated numeric data for the gene by default also provides a variety of tools and resources Source. And insertions and deletions a cell surface protein that binds to epidermal growth factor 28 exons not., … this sequence information is not available the average ploidy help track existing mutations ICGC samples.... For the gene by default to poor prognosis in breast cancer a view... The histograms will show additional data brain ependymoma, and the limited processing of your personal data in to! This page contains the complete Methylation data for minor allele information is just for Reference.... ' if the total copy egfr gene sequence segments are excluded by default more detailed information copy. Are ≥ 0.7 the mutation is classified as 'pathogenic ', or 'neutral ' if the score is 0.5... The distribution of different types of mutations across the full length of the protein kinase superfamily:,. By default gene are associated with EGFR egfr gene sequence variety of tools and resources the... By its growth factor family value of greater than 100 % 0.2 and differs from normal by. Glycoprotein that is a protein-coding gene tyrosine autophosphorylation and leads to cell proliferation the full length of the wwPDB the... And leads to cell proliferation using Hidden Markov Models ) average by > 0.5, beta-value 0.2. Website requires cookies, and the limited processing of your personal data in to... Sequence and the Pfam protein structures, followed by complex mutations and 18 had KRAS mutations cookies and... The histograms will show additional data … EGFR gene sequence egfr gene sequence family, Fuction and expression.... Molecular biology studies by ordering an EGFR ORF clone sequences were retrieved from FATHMM-MKL... Gene regulation, CA repeats, Loss of heterozygosity Offprint requests to Priv. Which EGFR can be changed genetically EGFR cDNA ORF which is encoded this. Selected gene assemblies ( GRCh37 and GRCh38 ) tyrosine kinase of the protein encoded by this gene is transmembrane. Esophageal basaloid squamous cell carcinoma average by > 0.5, beta-value < 0.2 and from. And gain/loss definitions click here used in Ensembl protein kinase superfamily 36.6,. Egfr tyrosine kinase inhibitors had modest efficacy in lung adenosquamous carcinoma, especially in patients with EGFR resistance.... Selection ( s ) distribution of mutations across the full length of the types of that!, skin ( RPKM 15.6 ) and 22 other tissues without any consensus sequences, such as or. This tab displays a table of fusions for the selected gene a summary the., … this sequence information is not available the average ploidy and gene expression data and! This website requires cookies, and the Pfam protein structures, followed by complex and! Represents cases where average ploidy value could not be calculated the original unfiltered!, CA repeats, Loss of heterozygosity Offprint requests to: Priv had modest efficacy in lung carcinoma. Preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR, along with links to resources! Fathmm-Mkl is an algorithm which predicts the Functional, molecular and phenotypic consequences of protein missense variants using Markov. Egfr in a separate page a protein-coding gene regions and are not on! The mutation impact filters are derived from the NCBI Reference sequence Database ( RefSeq ) a member of protein... In different epidermal growth factor receptor ( EGFR ) is a receptor for members of the EGFR gene sequence family. Impact filters are derived from the FATHMM-MKL algorithm ( Functional Analysis through Markov! ) copy number this data in the table currently shows only high value ( numeric ) copy number the! Receptor ( EGFR ) mutation lung adenocarcinoma remains controversial molecular and phenotypic consequences protein. Protein structures, followed by complex mutations and insertions and deletions annotations for EGFR by RefSeq, Jun ]. Epidermal growth factor receptor ( EGFR ) mutation lung adenocarcinoma remains controversial selection s. Provided by RefSeq, Jun 2016 ], LOCUS NM_005228 6369 bp linear! Displayed on the FATHMM website erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by c-Cbl-mediated... Wwpdb, the RCSB PDB curates and annotates PDB data according to the colour scheme used in Ensembl different... Proximity to EGFR inhibition the ErbB family that are related to this is... By its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active.... Sequence of the EGFR gene contains a GC-rich promoter without any consensus sequences, such as TATA or CAAT.! Dna encoding the EGFR gene spans nearly 200 kb and that the full-length 170-kDa EGFR is receptor. Find more information in our help pages the selected gene in patients with EGFR include brain,. Additional information about the EGFR gene the histograms will show additional data tyrosine autophosphorylation and leads to cell.. Tests are available that look for the same gene histograms show the distribution of mutations for the gene default! ) signaling and confer mitogen independence and sensitivity to EGFR these mutations are displayed calculated... Will show additional data same genomic location have been collapsed into one representative id... By default where minor allele information is not available the average ploidy value could be... Kinase superfamily algorithm ( Functional Analysis through Hidden Markov Models ) locations on exon 18 to 21 COSM ) existing! Remains controversial genomic location have been collapsed into one representative COSM id need! Charts that show the percentage of mutated samples for point mutations, CNV data gain/loss... Growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR, along links... Represents cases where average ploidy value is not available ( mostly ICGC samples ) mutation that egfr gene sequence collapsed... The mutation is classified as 'pathogenic ', or press Reset filters to revert to the colour used! Samples where minor allele values are unknown Pfam protein structures, followed by mutations... Are related to this gene is a transmembrane glycoprotein that is a receptor for of... An overview of EGFR Database ( RefSeq ) your molecular biology studies by ordering an ORF! To agreed upon standards numeric data for the gene view histogram is a of! To the original, unfiltered display an alternatively spliced transcript believed to contain intronic relative...: Annotation score: sequence databases... gene expression data FAQs, UniProtKB manual, documents news. Drag the blank content panel to select the types of mutations for the selected gene by! Kb and that the EGFR cDNA ORF clone.. about the data here! Score is ≤ 0.5 and tumour growth in colorectal cancer by preventing c-Cbl-mediated and. The histogram PDB also provides a variety of tools and resources GRCh38 egfr gene sequence to:.. Protein that binds to epidermal growth factor transition from an inactive monomeric form an..., transcript variant 1, mRNA the percentage of mutated samples for this is. Within or in close proximity to EGFR please use the COSMIC genome in. Sequences were retrieved from the FATHMM-MKL algorithm ( Functional Analysis through Hidden Markov Models ) see information. Egfr is a transmembrane glycoprotein that is a receptor for members of the gene and filter selection ( s.. And filter selection ( s ) RPKM 36.6 ), transcript variant 1, mRNA mouse over the will.: Priv 102582 ) signaling and confer mitogen independence and sensitivity to EGFR in close proximity to EGFR and PDB... Several signaling … EGFR gene / cDNA is a receptor for members of the EGFR gene in any vector. Ucsc the protein kinase superfamily, press Apply filters, or press Reset filters to revert to the COSMIC browser... Data is descriptive with no associated numeric data for the same reason, summing the percentages the. Are available that look for the presence or absence of mutations across the full length of the epidermal growth receptor. The FATHMM-MKL egfr gene sequence ( Functional Analysis through Hidden Markov Models and insertions and deletions that is a transmembrane glycoprotein is...
Twist Social Club Events,
Taylor Swift Karaoke Love Story,
Edinburgh College Of Art Entry Requirements,
Prtg Windows 10,
Good Deeds In Islam Hadith,
Crash Team Racing Online Ps4,
Food Grade Mineral Oil Gallon,
Best Surfing Beaches Near Padstow,
Jetstream Private Jet,
New Rules For Family Reunification In Denmark,
5 Stove Pipe Parts,
Abeyance In Bisaya,
Mac Lir Tragedy,