Ito K, Lim S, Caramori G, et al. While theophylline has more than one mechanism of action, inhibition of phosphodiesterase seems a likely contributor to its therapeutic effects in treating asthma. Mediators Inflamm 2012; 2012:492901.
Theophylline causes an increase in the concentration of cAMP in the cell through inhibition of phosphodiesterase-3 and 4. Theophylline antagonizes the negative chronotropic and dromotropic action of adenosine by blocking extracellular adenosine receptors [5]. Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Theophylline is a naturally occurring plant alkaloid related to caffeine and theobromine. Mechanism of Action: Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).
Never use theophylline in larger amounts, or for longer than prescribed. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being …
Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. Theophylline is given systemically (orally as slow-release preparations for chronic treatment and intravenously for acute exacerbations of asthma).
Theophylline, also known as 1,3-dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Corticosteroids act, at least in part, by recruitment of histone deacetylases (HDACs) to the site of active inflammatory gene transcription. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Learn who it’s for, how it works, its side effects, warnings, and more. Indications: treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.
The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling asthma. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic … It has two different mechanisms of action in people with reversible lung obstruction: as a bronchodilator, it causes smooth muscle relaxation. This cause bronchodialatation, cardiac stimulation and vasodilatation. How does theophylline for COPD work? Theophylline may also be used for purposes not listed in this medication guide. Its non-bronchodilator effects suppress the response of the airways to stimuli. Mechanism of Action of Theophylline It inhibit phosphodiesterase enzyme which degrades cyclic nucleotides intracellularly and it results the cyclic AMP accumulation in the cell. Theophylline is an oral medication used to treat asthma and other lung diseases. Through this mechanism, theophylline also reverses corticosteroid resistance, and this may be of particular value in severe asthma and COPD, wherein histone deacetylase-2 activity is reduced.
Mechanism of Action. Low dose theophylline showed an inhibitory effect on the production of IL-6 and IL-8 in primary lung fibroblast from patients with COPD.
Theophylline is part of the methylxanthines class.
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