Proteinuria is defined as a urinary protein excretion of > 150 mg/day. Serum studies show a calcium concentration of 13.4 mg/dL, urinalysis shows Bence JOnes proteins. Bence-Jones proteinuria - IgG light chains CBC - anemia, thrombocytopenia periph smear - rouleaux RBC electrolytes - low-anion gap full-body skeletal survey - punched-out lytic lesions bone scan - neg. Bone lesions and renal failure are uncommon in WM. Which of the following is the most likely cause of this patient;s hypercalcemia? High yield hallmark findings for USMLE Step 1 Collection of 100+ important findings that are high yield for a medical students. Courtesy of Madeleine Moussa, MD, FRCPC, Department of Pathology, London Health Sciences Centre, London, Ontario, Canada. hey stefan hope you dont sue me for copyright infringement! Serum protein electrophoresis will show a clonal IgM spike. Light chain–associated renal disorders. This is important for USMLE Step 1 or other equivalent exams. ( these are ur type questions :P) bone marrow aspiration ≥ 10% clonal plasma cells ; multiple plasma cells … Fewer than 10% of cases will have Bence-Jones proteinuria. Bence-Jones protein precipitates on heating (around 40-60), then redissolves just before the urine boils. rouleaux formation of red blood cells "stack of coins" appearance; Invasive studies . It has many possible causes, which may be benign (e.g., fever , intense exercise, dehydration ) or more serious (e.g., glomerulonephritis , multiple myeloma ). bone marrow Bx - > 10% plasma cells confirms UA - detects albumin need specific test for Bence-Jones protein that involves acidification of urine besides multiple myeloma two more conditions where you find these? Paraprotein appears as a sharp peak (a "spike"), most often … Ultrastructure (electron microscopy at 29,000X power) showing deposition of nonfibrillar electron-dense material in the mesangial nodule (arrow). Cram.com makes it easy to get the grade you want! 02:24 But Bence Jones just means light chains. 02:21 And there could be issues with the kidney or Bence Jones protein. 02:27 You can find light chains in other diseases. Bence Jones protein on urine electrophoresis; hypercalcemia; hypercalcemia ; protein electrophoresis of the serum (SPEP) monoclonal immunoglobulin spike (M protein) peripheral blood smear. Study Flashcards On USMLE step 1 flashcards (complete) at Cram.com. Excessive parathyroid hormone production Excessive parathyroid hormone related protein production Increased fractional calcium gastrointestinal absorption Time is important factor in the studies Video is made very short & all information is given in short video. Quickly memorize the terms, phrases and much more. A skeletal survey not usually required if the patient does not report bone pain. Initial 24-hour urine collection usually not required if no signs of renal insufficiency.
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